Design and development of technologies (R&D)

One of our main interest is the design and development of innovative technologies, equipment suitable for continuous processing and manufacturing of pharmaceutical intermediates (granules, nanoparticles, powders, nanofibrous materials, ASDs, etc.) and/or end products (granules, pellets, tablets or capsules).

Our recent articles

A. Balogh, B. Farkas, A. Domokos, A. Farkas, B. Démuth, E. Borbás, B. Nagy, G. Marosi, Z.K. Nagy, Controlled-release solid dispersions of Eudragit ® FS 100 and poorly soluble spironolactone prepared by electrospinning and melt extrusion, Eur. Polym. J. 95 (2017) 406–417. PDF

T. Vigh, B. Démuth, A. Balogh, D.L. Galata, I. Van Assche, C. Mackie, M. Vialpando, B. Van Hove, P. Psathas, E. Borbás, H. Pataki, P. Boeykens, G. Marosi, G. Verreck, Z.K. Nagy, Oral bioavailability enhancement of flubendazole by developing nanofibrous solid dosage forms, Drug Dev. Ind. Pharm. (2017) 1–8. LINK

A. Balogh, B. Farkas, Á. Pálvölgyi, A. Domokos, B. Démuth, G. Marosi, Z.K. Nagy, Novel alternating current electrospinning of hydroxypropylmethylcellulose acetate succinate (HPMCAS) nanofibers for dissolution enhancement: the importance of solution conductivity, J. Pharm. Sci. 106 (2017) 1634–1643. PDF

A. Farkas, B. Nagy, B. Démuth, A. Balogh, H. Pataki, Z.K. Nagy, G. Marosi, Variable clustering and spectral angle mapper-orthogonal projection method for Raman mapping of compound detection in tablets, J. Chemom. (2016). LINK

G. Varró, L. Hegedűs, A. Simon, A. Balogh, A. Grün, I. Leveles, B.G. Vértessy, I. Kádas, The First Enantioselective Total Synthesis of (−)-trans-Dihydronarciclasine, J. Nat. Prod. 80 (2017) 1909–1917. LINK

A. Balogh, B. Farkas, G. Verreck, J. Mensch, E. Borbás, B. Nagy, et al., AC and DC electrospinning of hydroxypropylmethylcellulose with polyethylene oxides as secondary polymer for improved drug dissolution, Int. J. Pharm. 505 (2016) 159–166. PDF

B. Démuth, A. Farkas, A. Balogh, K. Bartosiewicz, B. Kállai-Szabó, J. Bertels, et al., Lubricant-induced crystallization of itraconazole from tablets made of electrospun amorphous solid dispersion, J. Pharm. Sci. (2016). LINK

B. Nagy, A. Farkas, A. Balogh, H. Pataki, B. Vajna, Z.K. Nagy, et al., Quantification and handling of nonlinearity in Raman micro-spectrometry of pharmaceuticals, J. Pharm. Biomed. Anal. 128 (2016) 236–246. PDF

E. Borbás, B. Sinkó, O. Tsinman, K. Tsinman, E. Kiserdei, B. Démuth, et al., Investigation and mathematical description of the real driving force of passive transport of drug molecules from supersaturated solutions, Mol. Pharm. (2016). LINK

B. Démuth, A. Farkas, H. Pataki, A. Balogh, B. Szabó, E. Borbás, et al., Detailed stability investigation of amorphous solid dispersions prepared by single-needle and high speed electrospinning, Int. J. Pharm. 498 (2016) 234–244. doi:10.1016/j.ijpharm.2015.12.029. PDF

Z. Fülöp, A. Balogh, P. Saokham, P. Jansook, T. Loftsson, Formation and stability assessment of self-assembled nanoparticles from large Mw chitosan and sulfobutylether-β-cyclodextrin, J. Drug Deliv. Sci. Technol. 30 (2015) 1–8. PDF

I. Wagner, Z.K. Nagy, P. Vass, C. Fehér, Z. Barta, T. Vigh, et al., Stable formulation of protein-type drug in electrospun polymeric fiber followed by tableting and scaling-up experiments, Polym. Adv. Technol. 26 (2015) 1461–1467. LINK

A. Balogh, R. Cselkó, B. Démuth, G. Verreck, J. Mensch, G. Marosi, et al., Alternating current electrospinning for preparation of fibrous drug delivery systems, Int. J. Pharm. 495 (2015) 75–80. PDF

E. Borbás, A. Balogh, K. Bocz, J. Müller, É. Kiserdei, T. Vigh, et al., In vitro dissolution-permeation evaluation of an electrospun cyclodextrin-based formulation of aripiprazole using μFluxTM, Int. J. Pharm. (2015). LINK

P.L. Sóti, Z.K. Nagy, G. Serneels, B. Vajna, A. Farkas, F. Van der Gucht, et al., Preparation and comparison of spray dried and electrospun bioresorbable drug delivery systems, Eur. Polym. J. 68 (2015) 671–679. doi:10.1016/j.eurpolymj.2015.03.035. LINK

B. Démuth, Z.K. Nagy, A. Balogh, T. Vigh, G. Marosi, G. Verreck, et al., Downstream processing of polymer-based amorphous solid dispersions to generate tablet formulations, Int. J. Pharm. 486 (2015) 268–286. PDF

A. Balogh, B. Farkas, K. Faragó, A. Farkas, I. Wagner, I. Van Assche, et al., Melt-blown and electrospun drug-loaded polymer fiber mats for dissolution enhancement : A comparative study, J. Pharm. Sci. 104 (2015) 1767–1776. PDF

A. Balogh, T. Horváthová, Z. Fülöp, T. Loftsson, A.H. Harasztos, G. Marosi, et al., Electroblowing and electrospinning of fibrous diclofenac sodium-cyclodextrin complex-based reconstitution injection, J. Drug Deliv. Sci. Technol. 26 (2015) 28–34. PDF

Z.K. Nagy, A. Balogh, B. Démuth, H. Pataki, T. Vigh, B. Szabó, et al., High speed electrospinning for scaled-up production of amorphous solid dispersion of itraconazole, Int. J. Pharm. 480 (2015) 137–142. PDF

I. Wagner, Z.K. Nagy, Á. Suhajda, H. Pataki, P. Sóti, T. Vigh, et al., Film coating as a new approach to prepare tablets containing long-term stable Lactobacillus acidophilus, Period. Polytech. Chem. Eng. 59 (2015) 96–103. PDF

A. Balogh, G. Drávavölgyi, K. Faragó, A. Farkas, T. Vigh, P.L. Sóti, et al., Plasticized drug-loaded melt electrospun polymer mats: Characterization, thermal degradation, and release kinetics, J. Pharm. Sci. 103 (2014) 1278–1287. PDF

T. Vigh, T. Horváthová, A. Balogh, P.L. Sóti, G. Drávavölgyi, Z.K. Nagy, et al., Polymer-free and polyvinylpirrolidone-based electrospun solid dosage forms for drug dissolution enhancement, Eur. J. Pharm. Sci. 49 (2013) 595–602. LINK

Z.K. Nagy, A. Balogh, G. Drávavölgyi, J. Ferguson, H. Pataki, B. Vajna, et al., Solvent-free melt electrospinning for preparation of fast dissolving drug delivery system and comparison with solvent-based electrospun and melt extruded systems., J. Pharm. Sci. 102 (2013) 508–17. PDF

Z.K. Nagy, A. Balogh, B. Vajna, A. Farkas, G. Patyi, Á. Kramarics, et al., Comparison of electrospun and extruded Soluplus®-based solid dosage forms of improved dissolution, J. Pharm. Sci. 101 (2012) 322–332. LINK

I. Wagner, H. Pataki, A. Balogh, Z.K. Nagy, A.H. Harasztos, Á. Suhajda, et al., Electrospun nanofibers for topical drug delivery, in: Eur. J. Pharm. Sci., 2011: pp. 148–149. LINK

Z.K. Nagy, A. Balogh, I. Wagner, P. Soti, H. Pataki, K. Molnar, et al., Nanofibrous drug delivery systems for enhanced dissolution prepared by electrospinning, in: Eur. J. Pharm. Sci., 2011: pp. 152–153. LINK

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The company focuses on development of pharmaceutical technologies, traditional and innovative formulations with strong analytical support.

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Location: Budapest, Hungary